No relation between angiotensin-converting enzyme gene polymorphism and smoking dependence
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15370463
DOI
10.1080/00365510410002760
PII: 46KMBYW1UHX6A4DV
Knihovny.cz E-resources
- MeSH
- Peptidyl-Dipeptidase A genetics MeSH
- Adult MeSH
- Genetic Predisposition to Disease MeSH
- Smoking * MeSH
- Middle Aged MeSH
- Humans MeSH
- Smoking Cessation MeSH
- Polymorphism, Genetic * MeSH
- Tobacco Use Disorder epidemiology genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czechoslovakia epidemiology MeSH
- Names of Substances
- Peptidyl-Dipeptidase A MeSH
BACKGROUND: Smoking as a major risk factor for development of cancer and cardiovascular disease is thought to be partially genetically determined. The aim of this study was to investigate whether there is an association between insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme (ACE) and smoking status and the number of cigarettes smoked per week. METHODS: Using polymerase chain reaction, I/D polymorphism was evaluated in the ACE gene in 1204 male and 1375 female representative Caucasians. Information about smoking status and number of cigarettes smoked per week was collected via a questionnaire. RESULTS: Frequencies of the alleles and genotypes of ACE I/D polymorphism did not differ between smokers, past smokers and individuals who had never smoked. No association was found between ACE I/D polymorphism and the number of cigarettes smoked per week, either in males or in females. CONCLUSION: I/D polymorphism in the ACE gene does not play any role in genetic determination of predisposition to smoking.
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