Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15446361
Knihovny.cz E-resources
- MeSH
- beta-Cyclodextrins * MeSH
- Chemical Warfare Agents poisoning MeSH
- Cholinesterase Inhibitors poisoning MeSH
- Cyclodextrins administration & dosage MeSH
- Decontamination * MeSH
- Skin Absorption * MeSH
- Rats MeSH
- Poisoning prevention & control MeSH
- Rats, Wistar MeSH
- Soman poisoning MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- beta-Cyclodextrins * MeSH
- betadex MeSH Browser
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Cyclodextrins MeSH
- Soman MeSH
Three decontamination solutions of beta-cyclodextrines were prepared. Their abilities to decontamine rat skin contamined with nerve agent soman were tested. Decontamination efficacy of the tested cyclodextrine solutions was compared with the same decontamination means but without the cyclodextrines. The efficacy of tested decontaminants was evaluated by the assessment of the ID50 values. Two decontamination prescriptions with cyclodextrines (tetraborate buffer and tetraborate buffer with acetone) do not show significantly better decontamination efficacies in comparison with prescriptions without cyclodextrines. Only in case of aqueous solution of 2-aminoethanol the addition of beta-cyclodextrine resulted in significant increase (32%) in decontamination efficacy.
Synthesis and disinfection effect of the pyridine-4-aldoxime based salts
