The nucleolus and transcription of ribosomal genes
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
15519693
DOI
10.1016/j.biolcel.2004.04.015
PII: S0248-4900(04)00124-8
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Cell Nucleolus genetics physiology ultrastructure MeSH
- Cell Cycle genetics physiology MeSH
- Chromatin physiology ultrastructure MeSH
- Transcription, Genetic genetics MeSH
- Humans MeSH
- Cell Proliferation MeSH
- Gene Expression Regulation MeSH
- DNA, Ribosomal genetics MeSH
- RNA, Ribosomal genetics MeSH
- RNA Polymerase I metabolism MeSH
- Microscopy, Electron, Transmission MeSH
- Gene Silencing physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Chromatin MeSH
- DNA, Ribosomal MeSH
- RNA, Ribosomal MeSH
- RNA Polymerase I MeSH
Ribosome biogenesis is a highly dynamic, steady-state nucleolar process that involves synthesis and maturation of rRNA, its transient interactions with non-ribosomal proteins and RNPs and assembly with ribosomal proteins. In the few years of the 21st century, an exciting progress in the molecular understanding of rRNA and ribosome biogenesis has taken place. In this review, we discuss the recent results on the regulation of rRNA synthesis in relation to the functional organization of the nucleolus, and put an emphasis on the situation encountered in mammalian somatic cells.
References provided by Crossref.org
Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?
Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments
Positioning of the NOR-bearing chromosomes in relation to nucleoli in daughter cells after mitosis
