The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15820528
DOI
10.1016/j.pbb.2005.01.012
PII: S0091-3057(05)00052-3
Knihovny.cz E-resources
- MeSH
- Acoustic Stimulation MeSH
- Excitatory Amino Acid Antagonists pharmacology MeSH
- Antipsychotic Agents pharmacology MeSH
- Benzodiazepines pharmacology MeSH
- Dibenzothiepins pharmacology MeSH
- Dizocilpine Maleate antagonists & inhibitors pharmacology MeSH
- Clozapine pharmacology MeSH
- Rats MeSH
- Olanzapine MeSH
- Rats, Wistar MeSH
- Receptor, Serotonin, 5-HT2A drug effects MeSH
- Receptors, Dopamine D2 agonists MeSH
- Receptors, Muscarinic drug effects MeSH
- Risperidone pharmacology MeSH
- Reflex, Startle drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Excitatory Amino Acid Antagonists MeSH
- Antipsychotic Agents MeSH
- Benzodiazepines MeSH
- Dibenzothiepins MeSH
- Dizocilpine Maleate MeSH
- Clozapine MeSH
- Olanzapine MeSH
- Receptor, Serotonin, 5-HT2A MeSH
- Receptors, Dopamine D2 MeSH
- Receptors, Muscarinic MeSH
- Risperidone MeSH
- zotepine MeSH Browser
Dizocilpine (MK-801; 0.3 mg/kg i.p.)-induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by "atypical" antipsychotics. In contrast, some findings indicate that not all of the "atypical" antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different "atypical" antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0.1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine (2.5 and 5 mg/kg) restored the deficits in PPI induced by MK-801. Additionally, we found a decrease of approximately 46% in PPI after administration of clozapine (5 mg/kg) and olanzapine (2.5 and 5 mg/kg) without MK-801 treatment. In summary, the four "atypical" antipsychotics had different efficacies to restore the disrupted PPI by MK-801. Only clozapine and olanzapin restored the MK-801-induced deficits in PPI.
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