In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- acetylcholinesterasa metabolismus MeSH
- cholinesterasové inhibitory farmakologie MeSH
- druhová specificita MeSH
- kinetika MeSH
- krysa rodu Rattus MeSH
- lidé MeSH
- mozek účinky léků enzymologie MeSH
- obidoxim chlorid metabolismus farmakologie MeSH
- oximy metabolismus farmakologie MeSH
- pralidoximové sloučeniny metabolismus farmakologie MeSH
- prasata MeSH
- pyridinové sloučeniny metabolismus farmakologie MeSH
- reaktivátory cholinesterázy farmakologie MeSH
- sarin farmakologie MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- 1,4-bis(2-hydroxyiminomethylpyridinium)butane MeSH Prohlížeč
- acetylcholinesterasa MeSH
- asoxime chloride MeSH Prohlížeč
- cholinesterasové inhibitory MeSH
- obidoxim chlorid MeSH
- oximy MeSH
- pralidoxime MeSH Prohlížeč
- pralidoximové sloučeniny MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
- sarin MeSH
In vitro as well as in vivo evaluation of the reactivating efficacy of various oximes against nerve agent-inhibited acetylcholinesterase has been usually done with the help of animal experiments. Nevertheless, previously published data indicate that the reactivation potency of oximes may be different in human and animal species, which may hamper the extrapolation of animal data to human data. Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. Our results show differences among the species, depending on the type of oxime, and indicate that data from animal experiments needs to be carefully evaluated before extrapolation to humans.
Citace poskytuje Crossref.org
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