Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16154951
DOI
10.1196/annals.1342.037
PII: 1048/1/355
Knihovny.cz E-resources
- MeSH
- Allosteric Regulation drug effects MeSH
- Time Factors MeSH
- Chlorocebus aethiops MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- COS Cells MeSH
- Physostigmine pharmacology MeSH
- Patch-Clamp Techniques MeSH
- Neurons drug effects physiology MeSH
- Receptors, Nicotinic metabolism MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cholinesterase Inhibitors MeSH
- Physostigmine MeSH
- Receptors, Nicotinic MeSH
The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
References provided by Crossref.org
From Frog Muscle to Brain Neurons: Joys and Sorrows in Neuroscience
