The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16164699
DOI
10.1111/j.1744-313x.2005.00530.x
PII: EJI530
Knihovny.cz E-resources
- MeSH
- Alleles * MeSH
- Chemokine CCL2 genetics immunology MeSH
- Genetic Predisposition to Disease genetics MeSH
- Myocardial Infarction genetics immunology MeSH
- Polymorphism, Single Nucleotide genetics immunology MeSH
- Coronary Disease genetics immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Predictive Value of Tests MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- CCL2 protein, human MeSH Browser
- Chemokine CCL2 MeSH
Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction.
References provided by Crossref.org
MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis
