The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
16164699
DOI
10.1111/j.1744-313x.2005.00530.x
PII: EJI530
Knihovny.cz E-zdroje
- MeSH
- alely * MeSH
- chemokin CCL2 genetika imunologie MeSH
- genetická predispozice k nemoci genetika MeSH
- infarkt myokardu genetika imunologie MeSH
- jednonukleotidový polymorfismus genetika imunologie MeSH
- koronární nemoc genetika imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prediktivní hodnota testů MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CCL2 protein, human MeSH Prohlížeč
- chemokin CCL2 MeSH
Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction.
Citace poskytuje Crossref.org
MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis
