Toll-like receptors. I. Structure, function and their ligands
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
16285209
PII: file/6187/fb2005a0027.pdf
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Intracellular Signaling Peptides and Proteins MeSH
- Humans MeSH
- Ligands * MeSH
- Mice MeSH
- Immunity, Innate MeSH
- Signal Transduction MeSH
- Toll-Like Receptor 2 metabolism MeSH
- Toll-Like Receptor 4 immunology metabolism MeSH
- Toll-Like Receptors chemistry metabolism physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Intracellular Signaling Peptides and Proteins MeSH
- Ligands * MeSH
- Toll-Like Receptor 2 MeSH
- Toll-Like Receptor 4 MeSH
- Toll-Like Receptors MeSH
The innate immune system senses invading microorganisms by a phylogenetically conserved family of proteins PRRs of which TLRs are ones of the most important. There are at least 10 different TLRs in humans and 11 in mice. They have in the course of evolution specialized for the recognition of conserved structures among microorganisms called PAMPs. Activation of TLRs results in induction of innate immunity mechanisms as well in development of antigen-specific adaptive immune responses, thus bridging innate and adaptive immunity.
Inflammation--a lifelong companion. Attempt at a non-analytical holistic view
