Interaction of DNA/polycation complexes with phospholipids: stabilizing strategy for gene delivery
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Sodium Chloride chemistry MeSH
- DNA administration & dosage chemistry MeSH
- Phospholipids chemistry MeSH
- Cations * MeSH
- Lipid Bilayers MeSH
- Nanostructures MeSH
- Polylysine chemistry MeSH
- Solutions MeSH
- Serum Albumin chemistry MeSH
- Gene Transfer Techniques MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Sodium Chloride MeSH
- DNA MeSH
- Phospholipids MeSH
- Cations * MeSH
- Lipid Bilayers MeSH
- Polylysine MeSH
- Solutions MeSH
- Serum Albumin MeSH
The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes. Interaction of DNA/polycation complex particles with lipid vesicles.
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