Antibody formation against beta-tubulin class III in response to brain trauma
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16377426
DOI
10.1016/j.brainresbull.2005.05.032
PII: S0361-9230(05)00455-7
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Immunoglobulin G blood MeSH
- Immunoglobulin M blood MeSH
- Humans MeSH
- Brain immunology MeSH
- Neurons immunology MeSH
- Brain Injuries blood immunology MeSH
- Tubulin immunology MeSH
- Antibody Formation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin G MeSH
- Immunoglobulin M MeSH
- Tubulin MeSH
Brain trauma typically leads to neuronal damage and loss. Assuming a transient autoimmune response to debris of the damaged neurones, we have monitored serum titres of IgG and IgM antibodies to beta-tubulin class III (betaTcIII), which is almost exclusively found in neuronal cytoskeletons. In 15 out of 18 patients, the peak of the IgG or IgM antibody titre appeared in the serum within 3 weeks of a brain trauma.
References provided by Crossref.org
Avidity of anti-neurocytoskeletal antibodies in cerebrospinal fluid and serum
