Polyhydroxylated sapphyrins: multisite non-metallic catalysts for activated phosphodiester hydrolysis
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
16402829
DOI
10.1021/ja0518474
Knihovny.cz E-zdroje
- MeSH
- difrakce rentgenového záření MeSH
- hydrolýza MeSH
- hydroxylace MeSH
- katalýza MeSH
- kinetika MeSH
- molekulární struktura MeSH
- nitrofenoly chemie MeSH
- porfyriny chemie MeSH
- vodíková vazba MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- bis(4-nitrophenyl)phosphate MeSH Prohlížeč
- nitrofenoly MeSH
- porfyriny MeSH
- sapphyrin MeSH Prohlížeč
Enhanced hydrolysis rates for the cleavage of bis(4-nitrophenyl)phosphate (BNPP), a model phosphodiester, may be achieved by using appropriately designed ditopic receptors containing the known phosphate-binding nucleus, sapphyrin, attached covalently to suitably oriented polyhydroxyl subunits. Evidence for the interaction between sapphyrin and BNPP comes from solid-state X-ray diffraction analysis of a diprotonated dihydroxylated sapphyrin-BNPP complex and from solution-phase (31)P NMR spectroscopic binding studies. The sapphyrins described in this paper may have a role to play as oligonucleotide cleavage agents.
Citace poskytuje Crossref.org
