Lyme borreliosis: insights into tick-/host-borrelia relations
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
Grantová podpora
R37 AI-24899
NIAID NIH HHS - United States
PubMed
16405291
DOI
10.14411/fp.2005.039
Knihovny.cz E-zdroje
- MeSH
- antigeny bakteriální imunologie MeSH
- arachnida jako vektory cytologie imunologie mikrobiologie MeSH
- Borrelia burgdorferi komplex * klasifikace genetika imunologie patogenita MeSH
- glykokonjugáty fyziologie MeSH
- hemocyty cytologie parazitologie MeSH
- interakce hostitele a parazita MeSH
- klíště cytologie imunologie mikrobiologie MeSH
- lektiny fyziologie MeSH
- lidé MeSH
- lymeská nemoc imunologie mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- antigeny bakteriální MeSH
- glykokonjugáty MeSH
- lektiny MeSH
Lyme borreliosis (LB) is a serious infectious disease of humans and some domestic animals in temperate regions of the Northern Hemisphere. It is caused by certain spirochetes in the Borrelia burgdorferi sensu lato (s.l.) species complex. The complex consists of 11 species (genospecies). Borrelia burgdorferi sensu stricto (s.s.), Borrelia garinii and Borrelia afzelii are the major agents of human disease. Borrelia burgdorferi s.l. species are transmitted mainly by ticks belonging to the Ixodes ricinus species complex plus a few additional species not currently assigned to the complex. B. burgdorferi infections may produce an acute or chronic disease with a wide array of clinical symptoms such as erythema migrans (EM), carditis, arthritis, neuroborreliosis, and acrodermatitis chronica atrophicans (ACA). Differences in LB spirochetes 'genospecies' and strains/isolates determine the occurrence and severity of this multi-system disease. Accurate and reliable identification of the LB spirochetes in ticks as well as knowledge of their prevalence are essential for prevention against the disease and development of an effective vaccine. An overview of the knowledge of molecular factors with emphasis on potential protein-carbohydrate interactions in the tick-borrelia system is the main focus of this review.
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