Lyme borreliosis: insights into tick-/host-borrelia relations
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Grant support
R37 AI-24899
NIAID NIH HHS - United States
PubMed
16405291
DOI
10.14411/fp.2005.039
Knihovny.cz E-resources
- MeSH
- Antigens, Bacterial immunology MeSH
- Arachnid Vectors cytology immunology microbiology MeSH
- Borrelia burgdorferi Group * classification genetics immunology pathogenicity MeSH
- Glycoconjugates physiology MeSH
- Hemocytes cytology parasitology MeSH
- Host-Parasite Interactions MeSH
- Ixodes cytology immunology microbiology MeSH
- Lectins physiology MeSH
- Humans MeSH
- Lyme Disease immunology microbiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Glycoconjugates MeSH
- Lectins MeSH
Lyme borreliosis (LB) is a serious infectious disease of humans and some domestic animals in temperate regions of the Northern Hemisphere. It is caused by certain spirochetes in the Borrelia burgdorferi sensu lato (s.l.) species complex. The complex consists of 11 species (genospecies). Borrelia burgdorferi sensu stricto (s.s.), Borrelia garinii and Borrelia afzelii are the major agents of human disease. Borrelia burgdorferi s.l. species are transmitted mainly by ticks belonging to the Ixodes ricinus species complex plus a few additional species not currently assigned to the complex. B. burgdorferi infections may produce an acute or chronic disease with a wide array of clinical symptoms such as erythema migrans (EM), carditis, arthritis, neuroborreliosis, and acrodermatitis chronica atrophicans (ACA). Differences in LB spirochetes 'genospecies' and strains/isolates determine the occurrence and severity of this multi-system disease. Accurate and reliable identification of the LB spirochetes in ticks as well as knowledge of their prevalence are essential for prevention against the disease and development of an effective vaccine. An overview of the knowledge of molecular factors with emphasis on potential protein-carbohydrate interactions in the tick-borrelia system is the main focus of this review.
References provided by Crossref.org
Role of Zoo-Housed Animals in the Ecology of Ticks and Tick-Borne Pathogens-A Review