Sentinel lymph node biopsy in parotid gland carcinoma
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16550012
DOI
10.1097/01.rlu.0000204202.25026.c0
PII: 00003072-200604000-00005
Knihovny.cz E-resources
- MeSH
- Sentinel Lymph Node Biopsy methods MeSH
- Neck Dissection MeSH
- Humans MeSH
- Lymphatic Metastasis diagnostic imaging pathology MeSH
- Parotid Neoplasms diagnostic imaging pathology MeSH
- Pilot Projects MeSH
- Radiopharmaceuticals MeSH
- Radionuclide Imaging MeSH
- Technetium Tc 99m Aggregated Albumin MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Radiopharmaceuticals MeSH
- Technetium Tc 99m Aggregated Albumin MeSH
- technetium Tc 99m nanocolloid MeSH Browser
Indications for elective neck dissection (ELND) and its extent in N0-staged patients with parotid gland carcinoma are inconsistent. Therefore, a pilot study was performed to test the feasibility and efficacy of radioguided sentinel lymph node biopsy (SLNB) in these tumors. A total of 6 patients underwent lymphoscintigraphy, SLNB, and level II-IV ELND. In 2 patients, the latter was extended to level V because the scans had revealed an additional sentinel lymph node (SLN) in this atypical nodal region. In all cases, the SLNs were detected intraoperatively. The SLNB exactly reflected the positive and negative histopathologic status of the remaining lymphatic basin in patients 1 and 4, respectively. One case of false negativity of SLNB could be explained by distortion of the lymphatic outflow resulting from intraparotid localization of lymphatic metastasis. The authors believe that the SLNB could provide reliable information on the status of regional lymph nodes, making it possible to base the neck dissection on the actual presence of the micrometastases and to detect metastatic tumors at unusual nodal levels.
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