The role of resistin in obesity-induced insulin resistance
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
16625816
Knihovny.cz E-resources
- MeSH
- Atherosclerosis etiology MeSH
- Insulin Resistance * MeSH
- Humans MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Disease Models, Animal MeSH
- Nerve Growth Factor physiology MeSH
- Obesity metabolism MeSH
- PPAR gamma agonists MeSH
- Proteins physiology MeSH
- Resistin physiology MeSH
- Inflammation etiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Intercellular Signaling Peptides and Proteins MeSH
- Nerve Growth Factor MeSH
- PPAR gamma MeSH
- Proteins MeSH
- Resistin MeSH
- Retnla protein, mouse MeSH Browser
Resistin is a 12.5-kDa polypeptide hormone produced by adipocytes and immunocompetent cells. It was originally proposed as a link between obesity and insulin resistance/diabetes. Later, studies revealed that substantial inter-species differences exist between the major sites of resistin production in rodents (adipocytes) and humans (immunocompetent cells). While in rodents resistin appears to have an important role in the development of liver insulin resistance, its role in humans is less clear, and it is probably involved in the regulation of inflammatory processes rather than in insulin sensitivity. Current experimental and clinical data concerning resistin physiology and pathophysiology, and its possible role in the development of insulin resistance and atherosclerosis are detailed in this review.
