Structure and function of the nucleolus in the spotlight
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
075834/04/Z
Wellcome Trust - United Kingdom
PubMed
16687244
DOI
10.1016/j.ceb.2006.04.008
PII: S0955-0674(06)00058-5
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Cell Nucleolus metabolism ultrastructure MeSH
- Microscopy, Electron methods MeSH
- Genes, rRNA MeSH
- Nuclear Proteins metabolism MeSH
- Gene Expression Regulation MeSH
- Ribosomes metabolism MeSH
- RNA Polymerase I metabolism MeSH
- RNA Transport MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Nuclear Proteins MeSH
- RNA Polymerase I MeSH
The nucleolus is the most obvious and clearly differentiated nuclear sub-compartment. It is where ribosome biogenesis takes place, but it is becoming clear that the nucleolus also has non-ribosomal functions. In this review we discuss recent progress in our understanding of how both ribosome biosynthesis and some non-ribosomal functions relate to observable nucleolar structure. We still do not have detailed enough information about the in situ organization of the various processes taking place in the nucleolus. However, the present power of light and electron microscopy techniques means that a description of the organization of nucleolar processes at the molecular level is now achievable, and the time is ripe for such an effort.
References provided by Crossref.org
Fluctuations of pol I and fibrillarin contents of the nucleoli
Reproduction of the FC/DFC units in nucleoli
Nucleolar DNA: the host and the guests
Pontin is localized in nucleolar fibrillar centers
