Apoptotic machinery: the Bcl-2 family proteins in the role of inspectors and superintendents
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
16696437
Knihovny.cz E-resources
- MeSH
- Apoptosis physiology MeSH
- Apoptosis Inducing Factor physiology MeSH
- Humans MeSH
- BH3 Interacting Domain Death Agonist Protein physiology MeSH
- bcl-2-Associated X Protein physiology MeSH
- Apoptosis Regulatory Proteins physiology MeSH
- Proto-Oncogene Proteins c-bcl-2 physiology MeSH
- Signal Transduction MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Apoptosis Inducing Factor MeSH
- BH3 Interacting Domain Death Agonist Protein MeSH
- bcl-2-Associated X Protein MeSH
- Apoptosis Regulatory Proteins MeSH
- Proto-Oncogene Proteins c-bcl-2 MeSH
Programmed cell death, apoptosis, plays an integral role in a variety of biological events, e.g. morphogenesis, removal of unwanted or harmful cells, tissue homeostasis etc. Members of the Bcl-2 family have been described as the key players in the regulation of the apoptotic process. This family consists of proteins that prevent apoptosis (Bcl-2-like) and two structurally distinct subgroups (Bax-like and BH3-only) that on the contrary promote cell death. Majority of their response is concentrated to the mitochondrial level. In this paper, besides reviewing some new information in this field we focused on how they interact among each other and on the way they sense and influence the death signals from the environment. Here, we compare Bcl-2 family to inspectors and superintendents since they supervise the manufacturing process of cell death and they determine whether the cell will die or it will resist and survive.
