IL-10 and TNF-beta gene polymorphisms have no major influence on lactate levels after cardiac surgery
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
16723241
DOI
10.1016/j.ejcts.2006.02.025
PII: S1010-7940(06)00179-5
Knihovny.cz E-zdroje
- MeSH
- biologické markery krev MeSH
- dospělí MeSH
- frekvence genu MeSH
- funkce levé komory srdeční MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- interleukin-10 genetika MeSH
- koronární bypass * MeSH
- kyselina mléčná krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfotoxin-alfa genetika MeSH
- mediátory zánětu krev MeSH
- polymorfismus genetický * MeSH
- pooperační období MeSH
- prospektivní studie MeSH
- senioři MeSH
- zánět krev genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- interleukin-10 MeSH
- kyselina mléčná MeSH
- lymfotoxin-alfa MeSH
- mediátory zánětu MeSH
OBJECTIVE: Lactate levels after cardiac surgery are influenced by different proinflammatory (TNF, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines. The goal of the study was to determine the relationship between polymorphism in the IL-10 (-1082G/A) and TNF-beta (+252G/A) genes and lactate levels in patients after cardiac surgery. METHODS: We performed prospective observational study in 168 consecutive adult patients without left ventricle dysfunction undergoing elective coronary artery bypass grafting. Lactic acid levels were documented at five different time points: 10 min after beginning of cardiopulmonary bypass, 40 min after cardiopulmonary bypass termination, and 30 min, 8h, and 16 h after the surgery. Genetic analysis for polymorphism was performed by mismatched polymerase chain reaction and restriction analysis. RESULTS: No association was found between single polymorphism in IL-10 or TNF-beta gene and lactate levels, but the carriers of IL-10/TNF-beta genotype combination +A/GG had significantly different course of lactate levels in time with decrease in lactate (in comparison with increase in other groups) at 8h after the surgery. CONCLUSIONS: IL-10 (-1082G/A) and TNF-beta (+252G/A) gene polymorphisms have a little, yet measurable influence on the time course of changes in lactate levels after cardiac surgery.
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