Antiviral acyclic nucleoside phosphonates structure activity studies
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
16857275
DOI
10.1016/j.antiviral.2006.06.002
PII: S0166-3542(06)00175-6
Knihovny.cz E-resources
- MeSH
- Antiviral Agents chemistry pharmacology MeSH
- DNA Viruses drug effects MeSH
- DNA Virus Infections drug therapy virology MeSH
- Humans MeSH
- Nucleosides chemistry pharmacology MeSH
- Organophosphonates chemistry pharmacology MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Antiviral Agents MeSH
- Nucleosides MeSH
- Organophosphonates MeSH
This review concerns acyclic nucleoside phosphonates (ANP) and describes the concept of the design of isopolar and isosteric nucleotide analogues resistant towards degradation by enzymes in vivo. It describes the development of research which led to the discovery of several structurally related potent antivirals and ultimately resulted in the development of drugs directed against HIV, HBV and DNA-virus infections in general, namely adefovir, cidofovir and tenofovir. In addition to these "classical compounds" the review describes the present development in the field of ANP, the "open-ring ANP" and discusses the present achievements, concept of prodrug design and application.
References provided by Crossref.org
A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid
