Antiviral acyclic nucleoside phosphonates structure activity studies
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
PubMed
16857275
DOI
10.1016/j.antiviral.2006.06.002
PII: S0166-3542(06)00175-6
Knihovny.cz E-zdroje
- MeSH
- antivirové látky chemie farmakologie MeSH
- DNA viry účinky léků MeSH
- infekce DNA virem farmakoterapie virologie MeSH
- lidé MeSH
- nukleosidy chemie farmakologie MeSH
- organofosfonáty chemie farmakologie MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- antivirové látky MeSH
- nukleosidy MeSH
- organofosfonáty MeSH
This review concerns acyclic nucleoside phosphonates (ANP) and describes the concept of the design of isopolar and isosteric nucleotide analogues resistant towards degradation by enzymes in vivo. It describes the development of research which led to the discovery of several structurally related potent antivirals and ultimately resulted in the development of drugs directed against HIV, HBV and DNA-virus infections in general, namely adefovir, cidofovir and tenofovir. In addition to these "classical compounds" the review describes the present development in the field of ANP, the "open-ring ANP" and discusses the present achievements, concept of prodrug design and application.
Citace poskytuje Crossref.org
A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid
