Porcine OGN and ASPN: mapping, polymorphisms and use for quantitative trait loci identification for growth and carcass traits in a Meishan x Piétrain intercross
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16879361
DOI
10.1111/j.1365-2052.2006.01480.x
PII: AGE1480
Knihovny.cz E-resources
- MeSH
- Glycoproteins genetics MeSH
- Polymorphism, Single Nucleotide * MeSH
- Crosses, Genetic MeSH
- Humans MeSH
- Quantitative Trait Loci * MeSH
- Chromosome Mapping MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Microsatellite Repeats MeSH
- Swine genetics growth & development MeSH
- Proteoglycans genetics MeSH
- Synteny MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Glycoproteins MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- OGN protein, human MeSH Browser
- Proteoglycans MeSH
The porcine orthologues of human chromosome HSA9q22.31 genes osteoglycin (OGN) and asporin (ASPN) were mapped to porcine chromosome SSC3 using linkage analysis and a somatic cell hybrid panel. This mapping was refined to SSC3q11 using fluorescence in situ hybridization. These results confirm the existence of a small conserved synteny group between SSC3 and HSA9. Polymorphisms were revealed in both genes, including a pentanucleotide microsatellite (SCZ003) in OGN and two single nucleotide polymorphisms (AM181682.1:g.780G>T and AM181682.1:g.825T>C) in ASPN. The two genes were included in a set of markers for quantitative trait loci (QTL) mapping on SSC3 in the Hohenheim Meishan x Piétrain F2 family. Major QTL for growth and carcass traits were centred in the ASPN-SW902 region.
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