Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
16942882
DOI
10.1016/j.bmc.2006.08.014
PII: S0968-0896(06)00675-4
Knihovny.cz E-zdroje
- MeSH
- adjuvancia farmaceutická chemická syntéza farmakokinetika MeSH
- estery MeSH
- karbamáty chemie farmakokinetika MeSH
- kožní absorpce účinky léků MeSH
- permeabilita MeSH
- prasata MeSH
- uhličitany * MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adjuvancia farmaceutická MeSH
- estery MeSH
- karbamáty MeSH
- transkarbam 12 MeSH Prohlížeč
- uhličitany * MeSH
Transkarbam 12 (5-(dodecyloxycarbonyl)pentylammonium-5-(dodecyloxycarbonyl)pentylcarbamate, T12) is a highly effective skin permeation enhancer. In this study, ester groups in the molecule of T12 were replaced by carbonate and carbamate ones, respectively. The in vitro permeation-enhancing activities were evaluated using porcine skin and compared with those of T12 and previously prepared series of amide, ketone, and alkyl analogs. According to the activities and behavior of the compounds in donor samples, ester group is essential for the activity of T12; its replacement not only decreases the enhancing potency, but is likely to change the mechanism of action.
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