The effect of hyaluronan combined with KI3 complex (Hyiodine wound dressing) on keratinocytes and immune cells
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Hemostatics pharmacology MeSH
- HL-60 Cells MeSH
- Immune System cytology drug effects MeSH
- Iodine pharmacology MeSH
- Iodides pharmacology MeSH
- Keratinocytes drug effects MeSH
- Hyaluronic Acid pharmacology MeSH
- Humans MeSH
- U937 Cells MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Hemostatics MeSH
- hyaluronan-iodine complex MeSH Browser
- Iodine MeSH
- Iodides MeSH
- Hyaluronic Acid MeSH
- Lugol's solution MeSH Browser
Hyiodine (high molecular weight hyaluronan combined with KI3 complex) is a new non-adhesive wound dressing which significantly improves the healing process. The aim of the study was to investigate the effects of Hyoidine on functional properties of isolated human keratinocytes and leukocytes, and on those of U937 and HL60 cell lines. While KI3 complex inhibited the viability and proliferation of the cells tested, Hyiodine did not have any significant effect. The expression of CD11b, CD62L and CD69 on PMNL, monocytes and lymphocytes, as well as the oxidative burst of blood neutrophils, were not changed. On the contrary, Hyiodine inhibited the PMA-activated oxidative burst and significantly increased the production of IL-6 and TNF-alpha by lymphocytes. It was concluded that hyaluronan content of Hyiodine reduces the toxic effect of KI3 complex on cells and speeds up the wound healing process by increasing the production of inflammatory cytokines.
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