The effect of hyaluronan combined with KI3 complex (Hyiodine wound dressing) on keratinocytes and immune cells
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- hemostatika farmakologie MeSH
- HL-60 buňky MeSH
- imunitní systém cytologie účinky léků MeSH
- jod farmakologie MeSH
- jodidy farmakologie MeSH
- keratinocyty účinky léků MeSH
- kyselina hyaluronová farmakologie MeSH
- lidé MeSH
- U937 buňky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- hemostatika MeSH
- hyaluronan-iodine complex MeSH Prohlížeč
- jod MeSH
- jodidy MeSH
- kyselina hyaluronová MeSH
- Lugol's solution MeSH Prohlížeč
Hyiodine (high molecular weight hyaluronan combined with KI3 complex) is a new non-adhesive wound dressing which significantly improves the healing process. The aim of the study was to investigate the effects of Hyoidine on functional properties of isolated human keratinocytes and leukocytes, and on those of U937 and HL60 cell lines. While KI3 complex inhibited the viability and proliferation of the cells tested, Hyiodine did not have any significant effect. The expression of CD11b, CD62L and CD69 on PMNL, monocytes and lymphocytes, as well as the oxidative burst of blood neutrophils, were not changed. On the contrary, Hyiodine inhibited the PMA-activated oxidative burst and significantly increased the production of IL-6 and TNF-alpha by lymphocytes. It was concluded that hyaluronan content of Hyiodine reduces the toxic effect of KI3 complex on cells and speeds up the wound healing process by increasing the production of inflammatory cytokines.
Zobrazit více v PubMed
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