Adjacent location of the bac gene and two-component regulatory system genes within the putative Streptococcus agalactiae pathogenicity island
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17004655
DOI
10.1007/bf02932127
Knihovny.cz E-resources
- MeSH
- Antigens, Bacterial genetics MeSH
- Bacterial Proteins genetics MeSH
- DNA, Bacterial analysis MeSH
- Virulence Factors genetics MeSH
- Genomic Islands genetics MeSH
- Humans MeSH
- Molecular Sequence Data MeSH
- Gene Expression Regulation, Bacterial genetics MeSH
- Sequence Homology, Nucleic Acid MeSH
- Streptococcus agalactiae * genetics pathogenicity MeSH
- Streptococcus pneumoniae genetics MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Bacterial Proteins MeSH
- DNA, Bacterial MeSH
- Virulence Factors MeSH
A chromosomal DNA fragment of 8992 bp in size that has not been previously identified in Streptococcus agalactiae, was cloned and sequenced from strain 98-D60C. In particular, this 8992-bp fragment contained genes homologous to the sensor histidine kinase gene and the DNA-binding response-regulator gene of Streptococcus pneumoniae, and S. agalactiae bac gene. Structural and genetic features of the 8992-bp fragment were highly similar to those specific for bacterial pathogenicity islands. Analysis of epidemiologically unrelated S. agalactiae strains revealed that this fragment was present only in bac gene-positive strains. The possible origin of the 8992-bp fragment in S. agalactiae and its significance for molecular mechanisms of "bacteria-host" interactions are discussed.
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GENBANK
AY598359
