Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17184143
DOI
10.33549/physiolres.931089
PII: 1089
Knihovny.cz E-resources
- MeSH
- Adipokines blood MeSH
- Adiponectin blood MeSH
- Adiposity MeSH
- Models, Biological MeSH
- Adult MeSH
- Body Mass Index MeSH
- Insulin blood MeSH
- Insulin Resistance * MeSH
- Blood Glucose metabolism MeSH
- Leptin blood MeSH
- Humans MeSH
- Anorexia Nervosa blood physiopathology MeSH
- Resistin blood MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adipokines MeSH
- Adiponectin MeSH
- ADIPOQ protein, human MeSH Browser
- Insulin MeSH
- Blood Glucose MeSH
- Leptin MeSH
- Resistin MeSH
- RETN protein, human MeSH Browser
Anorexia nervosa (AN) is characterized by self-induced starvation leading to severe weight and fat loss. In the present study, we measured fasting plasma levels of adiponectin, leptin, resistin, insulin and glucose in 10 women with a restrictive type of AN and in 12 healthy women (C). Insulin sensitivity was determined according to homeostasis model assessment of insulin resistance (HOMA-R). Plasma resistin, leptin and insulin levels were significantly decreased, whereas plasma adiponectin levels were significantly increased in patients with AN compared to the C. HOMA-R was significantly decreased in patients with AN compared to the C group. Plasma adiponectin and leptin concentrations negatively and positively correlated with the body mass index and percentage body fat in both groups. Plasma adiponectin levels were negatively related to plasma insulin levels in the AN group only. In conclusion, we demonstrated that AN is associated with significantly decreased plasma leptin and resistin levels, markedly increased plasma adiponectin levels and increased insulin sensitivity. Plasma leptin and adiponectin levels were related to the body size and adiposity. Hyperadiponectinemia could play a role in increased insulin sensitivity of patients with AN. Neither body size and adiposity nor insulin sensitivity are the major determinants of plasma resistin levels in AN.
References provided by Crossref.org