Proteomic analysis of antibody response in a case of laboratory-acquired infection with Francisella tularensis subsp. tularensis
Language English Country United States Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17575919
DOI
10.1007/bf02932159
Knihovny.cz E-resources
- MeSH
- Electrophoresis, Gel, Two-Dimensional MeSH
- Antigens, Bacterial immunology isolation & purification MeSH
- Bacterial Proteins immunology isolation & purification MeSH
- Time Factors MeSH
- Francisella tularensis immunology MeSH
- Mass Spectrometry MeSH
- Immunoblotting MeSH
- Laboratory Infection blood MeSH
- Humans MeSH
- Antibodies, Bacterial blood immunology MeSH
- Antibody Specificity MeSH
- Tularemia blood MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Bacterial Proteins MeSH
- Antibodies, Bacterial MeSH
Immunoproteomic analysis was applied to study the immunoreactivity of serum samples collected at different time points from a laboratory assistant accidentally infected with highly virulent strain of Francisella tularensis subsp. tularensis. Immunoblotting showed that the spectrum of F. tularensis antigens recognized specifically by immune sera remained with the exception for 1 antigen stable for up to 16 years after infection. Using immunoproteomics approach 10 immunoreactive antigens were successfully identified. Several new immunogenic F. tularensis proteins were described for the first time.
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