Activities of respiratory chain complexes in isolated platelets in females with anorexia nervosa
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17584871
DOI
10.1002/eat.20403
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Electron Transport Chain Complex Proteins blood MeSH
- Humans MeSH
- Anorexia Nervosa blood MeSH
- Adolescent MeSH
- Case-Control Studies MeSH
- Blood Platelets metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Electron Transport Chain Complex Proteins MeSH
OBJECTIVE: A broad spectrum of endocrine and biochemical disturbances was observed in patients with anorexia nervosa. In addition, metabolic changes may concern the efficiency of mitochondrial energy generating system. In our study we analyzed the activities of respiratory chain complexes in females with anorexia nervosa. METHOD: The activities of respiratory chain complexes I, II, IV, I + III, and citrate synthase serving as the control enzyme were measured spectrophotometrically in isolated platelets in 36 females with anorexia nervosa (BMI 15 +/- 1.7) at the age 18-35 years and in 37 age related female controls (BMI 21 +/- 2.2). RESULTS: In females with anorexia nervosa, the activities of respiratory chain complexes I and II in isolated platelets were significantly higher in comparison with controls. No differences were found in the activities of complexes IV and I + III and citrate synthase. CONCLUSION: Our results suggest higher efficiency of some respiratory chain complexes in platelets in females with anorexia nervosa.
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