Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17660585
Knihovny.cz E-resources
- MeSH
- Stress, Physiological genetics physiopathology MeSH
- Hypoxia MeSH
- Immobilization MeSH
- Mice, Inbred Strains MeSH
- Inositol 1,4,5-Trisphosphate Receptors metabolism MeSH
- Myocytes, Cardiac metabolism pathology MeSH
- Rats MeSH
- Cells, Cultured MeSH
- RNA, Messenger analysis MeSH
- Mice MeSH
- Rats, Inbred SHR MeSH
- Rats, Inbred WKY MeSH
- Rats, Sprague-Dawley MeSH
- Receptors, sigma genetics metabolism MeSH
- Gene Expression Regulation * MeSH
- RNA Interference MeSH
- Heart Ventricles metabolism physiopathology MeSH
- Hypothermia, Induced MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Inositol 1,4,5-Trisphosphate Receptors MeSH
- RNA, Messenger MeSH
- Receptors, sigma MeSH
The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptor's mRNA levels. Signalling cascade of sigma receptors is dependent on IP(3) receptors, since silencing of both, type 1 and 2 IP(3) receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.
Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through σ1R/IP3R1 Complex
