The effect of flavonoid derivatives on doxorubicin transport and metabolism
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18024139
DOI
10.1016/j.bmc.2007.10.093
PII: S0968-0896(07)00959-5
Knihovny.cz E-resources
- MeSH
- Benzofurans pharmacology MeSH
- Biological Transport drug effects MeSH
- Doxorubicin analogs & derivatives metabolism pharmacokinetics MeSH
- Flavonoids chemistry pharmacology MeSH
- Humans MeSH
- Metabolism drug effects MeSH
- Cell Line, Tumor MeSH
- Breast Neoplasms MeSH
- Antibiotics, Antineoplastic MeSH
- Quercetin pharmacology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- adriamycinol MeSH Browser
- aurone MeSH Browser
- Benzofurans MeSH
- Doxorubicin MeSH
- Flavonoids MeSH
- Antibiotics, Antineoplastic MeSH
- Quercetin MeSH
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.
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