Der wundheilende Effekt einer Symphytum-Herba-Extrakt-Creme (Symphytum x uplandicum Nyman): Ergebnisse einer randomisierten, kontrollierten Doppelblindstudie
[Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study]
Jazyk němčina Země Rakousko Médium print
Typ dokumentu klinické zkoušky, fáze IV, anglický abstrakt, časopisecké články, multicentrická studie, randomizované kontrolované studie
- MeSH
- dítě MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- fytoterapie * MeSH
- hojení ran účinky léků MeSH
- kostival lékařský * MeSH
- kůže zranění MeSH
- lidé středního věku MeSH
- lidé MeSH
- masti MeSH
- měření bolesti MeSH
- mladiství MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- rostlinné extrakty terapeutické užití MeSH
- senioři MeSH
- sportovní úrazy farmakoterapie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- klinické zkoušky, fáze IV MeSH
- multicentrická studie MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- masti MeSH
- rostlinné extrakty MeSH
- Traumaplant MeSH Prohlížeč
METHOD: Wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN: ) were examined in a randomized clinical double-blind study including 278 patients with fresh abrasions (verum: n = 137), among them 64 patients of up to 20 years of age (verum n = 29, reference product n = 35). An otherwise identical low-dose preparation (1 % active ingredient; n = 141) was used as a reference. RESULTS: After 2-3 days of application of the study medication a highly significantly and clinically relevantly faster initial reduction of wound size of 49 + or - 19 % versus 29 + or - 13 % per day in favour of verum (p < 5x10(-21)) was found. From linear regression time to complete healing was determined to be 2.97 days faster with verum than with reference (4.08 vs. 7.05 days, p = 7.4 x 10(-45) in the t-Test comparison of regression lines). The physicians rated efficacy as good to very good in 93.4 % of cases, as compared to 61.7 % in the group treated with the reference product (p = 2 x 10(-11)). On a scale of 0-100 verum was rated with 84.4 + or - 10.1 points by the patients themselves. The reference product was rated with 65.5 + or - 24.8 points (p = 6.1 x 10(-18)). In subgroup analyses no significant influence of abrasion area, gender and age on healing effects was found, albeit a tendency towards better effects with increasing age was observed. No adverse effects or problems with drug tolerability occurred. Specifically, cutaneous reactions were observed in none of the patients throughout the 10 day observation phase. CONCLUSIONS: Symphytum herb extract can be attributed distinct wound healing effects, effects that can explicitly be used in paediatry.
Zobrazit více v PubMed
Hippokrates. 1952 Oct 15;23(19):550-2 PubMed
Pediatr Pol. 1957 Dec;32(12):1353-60 PubMed
Wien Med Wochenschr. 2004 Nov;154(21-22):498-507 PubMed
Adv Skin Wound Care. 2006 Apr;19(3):138-47 PubMed
J Surg Res. 1984 Dec;37(6):453-63 PubMed
Adv Ther. 2000 Jul-Aug;17(4):204-10 PubMed
Med Klin. 1953 May 8;48(19):676-8 PubMed
Phytomedicine. 2004 Sep;11(6):470-7 PubMed
Pol Tyg Lek (Wars). 1955 Mar 14;10(11):333-5 PubMed
