Contents of pentosidine in the tissue of the intervertebral disc as an indicator of the human age
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18189072
Knihovny.cz E-resources
- MeSH
- Arginine analogs & derivatives analysis MeSH
- Lumbar Vertebrae MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Lysine analogs & derivatives analysis MeSH
- Intervertebral Disc chemistry MeSH
- Adolescent MeSH
- Glycation End Products, Advanced analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging metabolism MeSH
- Age Determination by Skeleton * MeSH
- Chromatography, High Pressure Liquid MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Arginine MeSH
- Lysine MeSH
- pentosidine MeSH Browser
- Glycation End Products, Advanced MeSH
The study deals with the post-translational modifications of proteins - glycation of the tissue of the intervertebral disc and determination of one of advanced glycation end's products - pentosidine in the relation to the age. Pentosidine was detected in the hydrolysate of the intervertebral discs from persons between the ages of 16 and 95 years. 142 samples were analysed by high performance liquid chromatography, and the detected amounts of pentosidine were processed statistically. The coefficient of correlation of dependence of the amount of pentosidine on the age amounts to r = 0.92. The results of the work testify to the fact that it is possible to use the detection of pentosidine in the tissue of the intervertebral disc for the estimation of the age. Nevertheless subsequent experiments should be done under different conditions post-mortem decomposition.
