Transkarbams with terminal branching as transdermal permeation enhancers
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18242986
DOI
10.1016/j.bmcl.2008.01.040
PII: S0960-894X(08)00055-3
Knihovny.cz E-resources
- MeSH
- Administration, Cutaneous MeSH
- Carbamates chemistry pharmacokinetics MeSH
- Skin Absorption drug effects MeSH
- Skin MeSH
- Permeability MeSH
- Swine MeSH
- Theophylline administration & dosage MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Carbamates MeSH
- Theophylline MeSH
Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.
References provided by Crossref.org
