Role of alpha1- and alpha2-adrenoceptors in the regulation of locomotion and spatial behavior in the active place avoidance task: a dose-response study
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18255226
DOI
10.1016/j.neulet.2008.01.013
PII: S0304-3940(08)00059-1
Knihovny.cz E-resources
- MeSH
- Adrenergic alpha-Antagonists pharmacology MeSH
- Adrenergic alpha-1 Receptor Antagonists MeSH
- Receptors, Adrenergic, alpha-1 metabolism MeSH
- Adrenergic alpha-2 Receptor Antagonists MeSH
- Receptors, Adrenergic, alpha-2 metabolism MeSH
- Receptors, Adrenergic, alpha drug effects metabolism MeSH
- Idazoxan pharmacology MeSH
- Rats MeSH
- Brain drug effects metabolism MeSH
- Motor Activity drug effects physiology MeSH
- Memory Disorders chemically induced physiopathology MeSH
- Rats, Long-Evans MeSH
- Prazosin pharmacology MeSH
- Avoidance Learning drug effects physiology MeSH
- Space Perception drug effects physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic alpha-Antagonists MeSH
- Adrenergic alpha-1 Receptor Antagonists MeSH
- Receptors, Adrenergic, alpha-1 MeSH
- Adrenergic alpha-2 Receptor Antagonists MeSH
- Receptors, Adrenergic, alpha-2 MeSH
- Receptors, Adrenergic, alpha MeSH
- Idazoxan MeSH
- Prazosin MeSH
Studies on the neurotransmitter substrate of locomotion and place navigation occupy a central position in behavioral neuroscience. Active allothetic place avoidance (AAPA) is a task, in which animals are trained to avoid a room frame defined stable sector on a continuously rotating arena. The aim of the present study was to test the effect of the blockage of alpha1- and alpha2-adrenoceptors, using specific antagonists prazosin and idazoxan, on the locomotor activity and spatial behavior in the AAPA task. Both prazosin and idazoxan at the highest doses (4 and 6 mg/kg, respectively) were found to decrease the locomotor activity in the AAPA and they also impaired navigational performance. The results suggest that antagonizing alpha-adrenoceptors with systemically administered drugs affects locomotor activity together with avoidance behavior and does not cause a purely cognitive deficit in the AAPA task.
References provided by Crossref.org
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation
