What is the role of neurotransmitter systems in cortical seizures?
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18481909
DOI
10.33549/physiolres.931605
PII: 1605
Knihovny.cz E-resources
- MeSH
- GABA-B Receptor Antagonists MeSH
- Anticonvulsants therapeutic use MeSH
- Electroencephalography MeSH
- Epilepsy drug therapy physiopathology MeSH
- Receptors, Glutamate metabolism MeSH
- Rats MeSH
- Cerebral Cortex physiopathology MeSH
- Synaptic Transmission * MeSH
- Neurotransmitter Agents metabolism MeSH
- Receptors, Purinergic P1 metabolism MeSH
- Receptors, GABA-A metabolism MeSH
- Receptors, GABA-B metabolism MeSH
- Receptors, Neurotransmitter metabolism MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- GABA-B Receptor Antagonists MeSH
- Anticonvulsants MeSH
- Receptors, Glutamate MeSH
- Neurotransmitter Agents MeSH
- Receptors, Purinergic P1 MeSH
- Receptors, GABA-A MeSH
- Receptors, GABA-B MeSH
- Receptors, Neurotransmitter MeSH
Epileptic afterdischarges (ADs) elicited by electrical stimulation of sensorimotor cortical area were used as a model to study the role of neurotransmitter systems in cortical seizures in three age groups of developing rats. Drugs augmenting inhibition mediated by GABAA receptors were found to suppress ADs in all age groups, their activity was usually more marked in younger than in 25-day-old rat pups. Drugs potentiating GABAB receptors exhibit lower efficacy and more complicated developmental profile than GABAA-ergic drugs. Effects of an antagonist of GABAB receptor--marked prolongation of ADs in all three age groups--suggest an important role of GABAB receptors in arrest of cortical seizures. Drugs affecting glutamate receptors exhibit variable effects, usually better expressed in older animals than in 12-day-old ones. No specific role for ionotropic as well as metabotropic glutamate receptors could be predicted. Activation of adenosinergic inhibitory modulatory system also exhibited anticonvulsant action in the present model. All three neurotransmitter systems probably participate in mechanisms of generation, maintenance and arrest of cortical seizures.
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