A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats
Language English Country Ireland Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
18547554
DOI
10.1016/j.cbi.2008.05.001
PII: S0009-2797(08)00255-X
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase metabolism MeSH
- Chemical Warfare Agents poisoning MeSH
- Enzyme Reactivators pharmacology MeSH
- Rats MeSH
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Organophosphate Poisoning * MeSH
- Oximes pharmacology MeSH
- Rats, Wistar MeSH
- Soman poisoning MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Chemical Warfare Agents MeSH
- cyclohexyl methylphosphonofluoridate MeSH Browser
- Enzyme Reactivators MeSH
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Oximes MeSH
- Soman MeSH
- tabun MeSH Browser
The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with soman, tabun or cyclosarin at a lethal dose corresponding to their LD(50) value. In vivo determined percentage of reactivation of soman-inhibited blood and brain acetylcholinesterase in poisoned rats showed that only the oxime HI-6 was able to reactivate soman-inhibited acetylcholinesterase in the peripheral (blood) as well as central (brain) compartment. In vivo determined percentage of reactivation of tabun-inhibited blood and brain acetylcholinesterase in poisoned rats showed that obidoxime is the most efficacious reactivator of tabun-inhibited acetylcholinesterase among studied oximes in the peripheral compartment (blood) while K074 seems to be the most efficacious reactivator of tabun-inhibited acetylcholinesterase among studied oximes in the central compartment (brain). In vivo determined percentage of reactivation of cyclosarin-inhibited blood and brain acetylcholinesterase in poisoned rats showed that HI-6 is the most efficacious reactivator of cyclosarin-inhibited acetylcholinesterase among studied oximes. Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute soman and cyclosarin poisonings.
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