A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
18547554
DOI
10.1016/j.cbi.2008.05.001
PII: S0009-2797(08)00255-X
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa metabolismus MeSH
- chemické bojové látky otrava MeSH
- enzymové reaktivátory farmakologie MeSH
- krysa rodu Rattus MeSH
- organofosfáty MeSH
- organofosforové sloučeniny MeSH
- otrava organofosfáty * MeSH
- oximy farmakologie MeSH
- potkani Wistar MeSH
- soman otrava MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- chemické bojové látky MeSH
- cyclohexyl methylphosphonofluoridate MeSH Prohlížeč
- enzymové reaktivátory MeSH
- organofosfáty MeSH
- organofosforové sloučeniny MeSH
- oximy MeSH
- soman MeSH
- tabun MeSH Prohlížeč
The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, HI-6) to reactivate nerve agent-inhibited acetylcholinesterase was evaluated in rats poisoned with soman, tabun or cyclosarin at a lethal dose corresponding to their LD(50) value. In vivo determined percentage of reactivation of soman-inhibited blood and brain acetylcholinesterase in poisoned rats showed that only the oxime HI-6 was able to reactivate soman-inhibited acetylcholinesterase in the peripheral (blood) as well as central (brain) compartment. In vivo determined percentage of reactivation of tabun-inhibited blood and brain acetylcholinesterase in poisoned rats showed that obidoxime is the most efficacious reactivator of tabun-inhibited acetylcholinesterase among studied oximes in the peripheral compartment (blood) while K074 seems to be the most efficacious reactivator of tabun-inhibited acetylcholinesterase among studied oximes in the central compartment (brain). In vivo determined percentage of reactivation of cyclosarin-inhibited blood and brain acetylcholinesterase in poisoned rats showed that HI-6 is the most efficacious reactivator of cyclosarin-inhibited acetylcholinesterase among studied oximes. Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute soman and cyclosarin poisonings.
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