Molecular crosstalks in Leishmania-sandfly-host relationships
Jazyk angličtina Země Francie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- dezinsekce metody MeSH
- hmyz - vektory imunologie parazitologie MeSH
- kousnutí a bodnutí hmyzem MeSH
- Leishmania izolace a purifikace MeSH
- leishmanióza parazitologie prevence a kontrola veterinární MeSH
- lidé MeSH
- protilátky analýza MeSH
- Psychodidae imunologie parazitologie MeSH
- sliny imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- protilátky MeSH
Sandflies (Diptera: Phlebotominael are vectors of Leishmania parasites, causative agents of important human and animal diseases with diverse manifestations. This review summarizes present knowledge about the vectorial part of Leishmania life cycle and parasite transmission to the vertebrate host. Particularly, it focuses on molecules that determine the establishment of parasite infection in sandfly midgut. It describes the concept of specific versus permissive sandfly vectors, explains the epidemiological consequences of broad susceptibility of permissive sandflies and demonstrates that genetic exchange may positively affect Leishmania fitness in the vector. Last but not least, the review describes recent knowledge about circulating antibodies produced by hosts in response to sandfly bites. Studies on specificity and kinetics of antibody response revealed that anti-saliva IgG could be used as a marker of host exposure to sandflies, i.e. as a useful tool for evaluation of vector control.
Citace poskytuje Crossref.org
