Comparison of different doses of antigen for intradermal administration in pigs: the Actinobacillus pleuropneumoniae model
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
18824203
DOI
10.1016/j.vaccine.2008.09.027
PII: S0264-410X(08)01218-8
Knihovny.cz E-resources
- MeSH
- Actinobacillus pleuropneumoniae immunology pathogenicity MeSH
- Antigens, Bacterial administration & dosage immunology MeSH
- Bacterial Vaccines MeSH
- Dose-Response Relationship, Immunologic MeSH
- Actinobacillus Infections immunology microbiology pathology prevention & control MeSH
- Injections, Intradermal MeSH
- Swine Diseases immunology microbiology pathology prevention & control MeSH
- Lung microbiology pathology MeSH
- Swine MeSH
- Antibodies, Bacterial blood MeSH
- Treatment Outcome MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Antigens, Bacterial MeSH
- Bacterial Vaccines MeSH
- Antibodies, Bacterial MeSH
The intensity of antibody responses and level of protection against challenge infection induced by Actinobacillus pleuropneumoniae (APP) were compared in piglets vaccinated intramuscularly with different vaccination doses of a subunit vaccine. Secondary antibody responses to APP exotoxins induced by the intradermally administered diluted vaccines did not differ from those induced by undiluted vaccines administered either intradermally or intramuscularly. The level of protection measured by the clinical course of challenge infection to the extent of lung lesions was significantly higher in animals vaccinated with a three-time diluted vaccine in comparison with animals that were administered intramuscularly or intradermally with the most concentrated or the most diluted vaccines.
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