HHV-6 DNA throughout the tissues of two stem cell transplant patients with chromosomally integrated HHV-6 and fatal CMV pneumonitis
Language English Country England, Great Britain Media print-electronic
Document type Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
19222466
DOI
10.1111/j.1365-2141.2009.07622.x
PII: BJH7622
Knihovny.cz E-resources
- MeSH
- Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality therapy virology MeSH
- Leukemia, Myeloid, Acute mortality therapy virology MeSH
- Cytomegalovirus Infections mortality MeSH
- Cytomegalovirus isolation & purification MeSH
- Child MeSH
- DNA, Viral analysis MeSH
- Adult MeSH
- Fatal Outcome MeSH
- Roseolovirus Infections genetics virology MeSH
- Virus Integration genetics MeSH
- Humans MeSH
- Chromosomes, Human virology MeSH
- Herpesvirus 6, Human genetics MeSH
- Lung virology MeSH
- Pneumonia mortality virology MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Hematopoietic Stem Cell Transplantation * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- DNA, Viral MeSH
Two patients with the characteristic high human herpesvirus 6 (HHV-6) DNA loads in peripheral blood caused by chromosomally integrated (CI) virus received a haematopoietic stem cell transplant (HSCT) from a donor without CI HHV-6. Both patients died in consequence of cytomegalovirus (CMV) pneumonitis. At autopsy, high amounts of CMV DNA were detected in lungs but at much lower levels in other organs. In contrast HHV-6 DNA was detected at high levels throughout the organs with the exception of donor-derived haematopoietic tissue. In individuals with chromosomal integration, HHV-6 DNA is found in every tissue of recipient origin indicating inheritance through the germ line.
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