The effect of the novel partial alpha2-adrenoceptor agonist naphthylmedetomidine on the basic cardiorespiratory parameters and behavior in rhesus monkeys
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
19239571
DOI
10.1111/j.1600-0684.2009.00347.x
PII: JMP347
Knihovny.cz E-zdroje
- MeSH
- agonisté adrenergních alfa-receptorů farmakologie MeSH
- alfa-2-adrenergní receptory - agonisté * MeSH
- anestetika disociativní aplikace a dávkování farmakologie MeSH
- chování zvířat účinky léků MeSH
- hemoglobiny metabolismus MeSH
- hyaluronoglukosaminidasa aplikace a dávkování farmakologie MeSH
- ketamin aplikace a dávkování farmakologie MeSH
- Macaca mulatta fyziologie MeSH
- medetomidin aplikace a dávkování analogy a deriváty farmakologie MeSH
- srdeční frekvence účinky léků MeSH
- triclosan metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 4-(1-(1-naphthyl)ethyl)imidazole MeSH Prohlížeč
- agonisté adrenergních alfa-receptorů MeSH
- alfa-2-adrenergní receptory - agonisté * MeSH
- anestetika disociativní MeSH
- hemoglobiny MeSH
- hyaluronoglukosaminidasa MeSH
- ketamin MeSH
- medetomidin MeSH
- triclosan MeSH
BACKGROUND: The aim of this study was to compare cardiorespiratory and behavioral profile of a new alpha 2-adrenoceptor ligand naphthylmedetomidine with medetomidine in rhesus monkeys. METHODS: Naphthylmedetomidine or medetomidine (50 microg/kg) together with ketamine (3 mg/kg) and hyaluronidase (150 IU/kg) i.m was administered to 35 rhesus monkeys. Behavioral changes were then observed together with blood pressure, heart rate and oxygen saturation of hemoglobin. RESULTS: The onset of sedation, ataxia, and reduction of aggression was similar in both treatment groups. Immobilization was observed only in medetomidine treated animals, while in naphthylmedetomidine treated animals loss of aggressiveness was observed but the animals never completely lost mobility. Naphthylmedetomidine showed less prominent effects on cardiorespiratory functions compared with medetomidine. CONCLUSIONS: Our results suggest that naphthylmedetomidine can be used to induce sedation in primates and other small animals while avoiding the serious side effects observed after administration of the currently used full alpha(2)-AR agonists.
Citace poskytuje Crossref.org
