PURPOSE: The aim of this experimental study was to test the method of prevention of postoperative complications, especially infectious, in partial dehiscence following stapler anastomosis in rectal surgeries. METHODS: The method includes the application of a hyaluronic acid-based gel in combination with triclosan, which has antibacterial properties. The gel was applied to the space around the rectum with an artificial, precisely defined dehiscence so that the dehiscence was separated from the rest of pelvis and the peritoneal cavity to avoid the spread of infection. The study included 30 female pigs. The rectosigmoid colon was mobilized and transected completely. Anastomosis was constructed with circular staplers. A perforator was then used to create precisely defined artificial dehiscence. Subsequently the lesser pelvis was filled with hyaluronic gel such that the site of artificial dehiscence was covered completely. RESULTS: All animals survived for 14 days until the second-look revision with no signs of failure in the anastomosis healing, local inflammation, and sepsis or postoperative complications, such as chills, refusal of liquid or feed, abdominal distension, and bowel obstruction. CONCLUSION: Hyaluronic acid applied as a precursor solution around the rectal anastomosis fills the lesser pelvis perfectly. It prevents the leakage of intestinal contents in the lesser pelvis. Triclosan as an antibacterial substance prevents the spread of inflammation in the pelvis or even in the abdominal cavity.
- MeSH
- anastomóza chirurgická metody MeSH
- antibakteriální látky terapeutické užití MeSH
- kyselina hyaluronová MeSH
- lidé MeSH
- nádory rekta * chirurgie MeSH
- netěsnost anastomózy MeSH
- pánev chirurgie MeSH
- pooperační komplikace prevence a kontrola MeSH
- prasata MeSH
- rektum chirurgie MeSH
- triclosan * MeSH
- zánět MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- arginin fyziologie MeSH
- biofilmy účinky léků MeSH
- chlorhexidin farmakologie škodlivé účinky terapeutické užití MeSH
- ionty farmakologie metabolismus škodlivé účinky terapeutické užití MeSH
- lidé MeSH
- probiotika terapeutické užití MeSH
- triclosan farmakologie terapeutické užití MeSH
- xylitol metabolismus terapeutické užití MeSH
- zubní čisticí prostředky analýza terapeutické užití MeSH
- zubní kaz * etiologie prevence a kontrola MeSH
- zubní plak * komplikace terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Due to their large active surface, high loading efficiency, and tunable dissolution profiles, nanofibrous mats are often cited as promising drug carriers or antimicrobial membranes. Hyaluronic acid has outstanding biocompatibility, but it is hydrophilic. Nanofibrous structures made from hyaluronan dissolve immediately, making them unsuitable for controlled drug release and longer applications. We aimed to prepare a hyaluronan-based antimicrobial nanofibrous material, which would retain its integrity in aqueous environments. Self-supporting nanofibrous mats containing octenidine dihydrochloride or triclosan were produced by electrospinning from hydrophobized hyaluronan modified with a symmetric lauric acid anhydride. The nanofibrous mats required no cross-linking to be stable in PBS for 7 days. The encapsulation efficiency of antiseptics was nearly 100%. Minimal release of octenidine was observed, while up to 30% of triclosan was gradually released in 72 h. The nanofibrous materials exhibited antimicrobial activity, the fibroblast viability was directly dependent on the antiseptic content and its release.
- MeSH
- antibakteriální látky chemie farmakologie toxicita MeSH
- buňky 3T3 MeSH
- hydrofobní a hydrofilní interakce MeSH
- iminy chemie farmakologie toxicita MeSH
- kyselina hyaluronová chemie farmakologie toxicita MeSH
- léky s prodlouženým účinkem chemie farmakologie toxicita MeSH
- mikrobiální testy citlivosti MeSH
- myši MeSH
- nanovlákna chemie toxicita MeSH
- nosiče léků chemie farmakologie toxicita MeSH
- Pseudomonas aeruginosa účinky léků MeSH
- pyridiny chemie farmakologie toxicita MeSH
- Staphylococcus aureus účinky léků MeSH
- triclosan chemie farmakologie toxicita MeSH
- uvolňování léčiv MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Úvod: Abdominálna hysterektómia je jednou z najčastejšie vykonávaných operácii v gynekológii. Šicí materiál polyglaktín 910 impregnovaný s antibakteriálnym činidlom triklosan môže znížiť frekvenciu infekčných pooperačných komplikácií a následne skrátiť dobu hospitalizácie. Materiál a metódy: Štúdie sa zúčastnilo 450 pacientok, ktoré podstúpili abdominálnu hysterektómiu v období od augusta 2008 do augusta 2018. Sledovali sa nasledovné premenné: C-reaktívny proteín, pooperačné užívanie antibiotík, maximálna telesná teplota, trvanie a náklady hospitalizácie. Výsledky: V skupine žien, u ktorých sa použil steh s triklosanom, bol zápalový marker CRP signifikatne nižší (p < 0,002) ako v skupine, kde sa použil konvenčný šicí materiál bez triclosanu. Rovnako tak bola v skupine žien s použitím šicieho materiálu s triklosanom významne nižšia maximálna telesná teplota počas celého obdobia hospitalizácie (p = 0,004), aplikácia pooperačných antibiotík bola signifikantne nižšia (p < 0,001), dĺžka pobytu v nemocnici bola signifikantne kratšia (p < 0,001) a náklady, počítané na lôžko dni, boli tiež signifikantne nižšie (p < 0,001). Záver: Usudzujeme, že aplikácia šicieho materiálu s triklosanom môže mať preventívne účinky na infekčné komplikácie. Najmä vaginálna rana je oblasť s najvyššou kolonizáciou patogénov. Preto najmä na sutúru pošvovej rany odporúčame aplikovať šicí material polyglaktín 910 potiahnutý triklosanom, aby sa eliminovalo riziko lokálnej infekcie.
Background: Abdominal hysterectomy is one of the most frequently performed surgical procedures in gynecology. The new coated polyglactin 910 sutures with the antibacterial agent triclosan may help to reduce the frequency of infectious postoperative complications and consequently shorten the duration of hospital stay. Materials and methods: The study was carried out with 450 patients who underwent abdominal hysterectomy between August 2008 and August 2018. The following factors were taken into account: C-reactive protein, the application of post-operative antibiotics, the maximum body temperature, the duration and the cost of hospitalization. Results: In those cases where triclosan-coated suture was used, the phlogistic C-reactive marker was significantly lower (p < 0.002) than in the group where conventional suture without triclosan was used, the maximum body temperature during the whole period of hospitalization was also significantly lower (p = 0.004), the application of post-operative antibiotics was significantly lower (p < 0.001), the length of hospital stay was significantly shorter (p < 0.001), and the costs, calculated in treatment days, were also significantly lower (p < 0.001). Conclusions: It can be concluded that the application of the sutural material with triclosan offers real benefits in the prevention of infectious complications. Particularly, the vaginal wound is the region with the highest colonization of pathogens. Therefore, for the suture of the vaginal wound in particular, we especially recommend applying triclosan-coated polyglactin 910 suture in order to eliminate the risk of local infection resulting directly from the use of the sutural material.
- MeSH
- antiinfekční látky lokální * MeSH
- hysterektomie * MeSH
- infekce chirurgické rány * prevence a kontrola MeSH
- lidé MeSH
- polyglactin 910 farmakologie MeSH
- pooperační komplikace MeSH
- sutura MeSH
- triclosan farmakologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
Tuberculosis (TB) represents one of the leading causes of morbidity and mortality worldwide. Development of new potential drugs is essential because of the existence of latent TB and expansion of drug-resistant TB forms (multidrug-resistant and extensively drug-resistant tuberculosis). Triclosan is a widely used broad-spectrum biocidal agent. It has been shown to inhibit InhA, an essential enoyl acyl carrier protein reductase, resulting in the lysis of Mycobacterium tuberculosis. Triclosan can be considered as a promising compound for the inhibition of InhA and suppression of mycobacterial growth, because this polychlorinated molecule doesn't require any activation and it is able to affect the function of InhA directly. This approach enables to circumvent resistance to isoniazid. The aim of this review is to describe current knowledge about triclosan and its analogues as potential antimycobacterial agents.
- MeSH
- antituberkulotika chemie farmakologie terapeutické užití MeSH
- bakteriální léková rezistence účinky léků fyziologie MeSH
- lidé MeSH
- Mycobacterium tuberculosis účinky léků fyziologie MeSH
- triclosan analogy a deriváty farmakologie terapeutické užití MeSH
- tuberkulóza farmakoterapie patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Klíčová slova
- zubní pasty Colgate herbal, Colgate total,
- MeSH
- čištění zubů metody MeSH
- citlivost dentinu farmakoterapie MeSH
- gingivitida farmakoterapie MeSH
- lidé MeSH
- triclosan aplikace a dávkování farmakologie MeSH
- zubní pasty * MeSH
- zubní plak farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- randomizované kontrolované studie MeSH
Sewage sludge is an important amendment that enriches soils with organic matter and provides plants with nutrients such as nitrogen and phosphorus. However, knowledge on the fate and effects of organic pollutants present in the sludge on soil organisms is limited. In the present study, the uptake of triclosan, galaxolide, and tonalide in the earthworm Dendrobaena veneta was measured 1 wk after amendment of agricultural soil with sewage sludge, while elimination kinetics were assessed over a 21-d period after transferring worms to clean soil. After 1-wk exposure, earthworms had accumulated 2.6 ± 0.6 μg g-1 galaxolide, 0.04 ± 0.02 μg g-1 tonalide, and 0.6 ± 0.2 μg g-1 triclosan. Both synthetic musks were efficiently excreted and below the limit of quantification after 3 and 14 d of depuration for tonalide and galaxolide, respectively. Triclosan concentrations, on the other hand, did not decrease significantly over the depuration period, which may lead to the transfer of triclosan in the food web. Environ Toxicol Chem 2017;36:2068-2073. © 2017 SETAC.
- MeSH
- benzopyrany analýza metabolismus toxicita MeSH
- dezinficiencia analýza metabolismus toxicita MeSH
- látky znečišťující půdu analýza toxicita MeSH
- odpadní vody chemie MeSH
- Oligochaeta účinky léků metabolismus MeSH
- potravní řetězec MeSH
- půda chemie MeSH
- tetrahydronaftaleny analýza metabolismus toxicita MeSH
- toxikokinetika MeSH
- triclosan analýza metabolismus toxicita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
At ecosystems level, environmental parameters such as temperature, pH, dissolved oxygen concentration and intensity of UV radiation (UVR) have an important role on the efficiency of organisms' physiological and behavioral performances and consequently on the capacity of response to contaminants. Insignificant alterations of these parameters may compromise this response. In addition, these parameters can additionally alter chemical compounds by inducing their degradation, producing thereafter other metabolites. Understanding the combined effects of chemicals and environmental parameters is absolutely necessary for an adequate prediction of risk in aquatic environments. According to this scenario, this work aims at studying the combined toxicity of UVR and three xenobiotics: the biocide triclosan (TCS), the metal chromium (as potassium dichromate, PD) and the fungicide prochloraz (PCZ). To achieve this goal zebrafish (Danio rerio) embryos (3h post fertilization (hpf)) were exposed to several concentrations of each chemical combined with different UV intensities; mortality and eggs were recorded every 24h for the all test duration (96 h). Results showed different response patterns depending on the toxicant, stress levels and duration of exposure. The combination of UVR and TCS indicated a dose ratio deviation where synergism was observed when UVR was the dominant stressor (day 2). The combination of UVR and PD presented a dose level dependency at day 3 indicating antagonism at low stress levels, changing with time where at day 4, a dose ratio deviation showed statistically that synergism occurred at higher PD concentrations. Finally, UVR combined with PCZ indicated a dose ratio at day 3 and dose level deviation at day 4 of exposure, suggesting a synergistic response when PCZ is the dominant stressor in the combination. The obtained results in this study highlighted the importance of taking into account the possible interaction of stressors and time of exposure to better predict environmental risk.
- MeSH
- antiinfekční látky lokální toxicita MeSH
- chemické látky znečišťující vodu toxicita MeSH
- dánio pruhované MeSH
- dvojchroman draselný toxicita MeSH
- embryo nesavčí účinky léků účinky záření MeSH
- fungicidy průmyslové toxicita MeSH
- imidazoly toxicita MeSH
- triclosan toxicita MeSH
- ultrafialové záření * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- antibakteriální látky * farmakologie chemická syntéza MeSH
- estery farmakologie chemická syntéza MeSH
- mikrobiální testy citlivosti * MeSH
- Mycobacterium avium účinky léků MeSH
- Mycobacterium kansasii účinky léků MeSH
- Mycobacterium tuberculosis účinky léků MeSH
- techniky in vitro MeSH
- triclosan * analogy a deriváty farmakologie chemická syntéza MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Klíčová slova
- hormonální disruptory, bisfenol A, ftaláty, nonylfenol, obezogeny,
- MeSH
- dioxiny analýza chemie metabolismus škodlivé účinky MeSH
- endokrinní disruptory * metabolismus normy škodlivé účinky MeSH
- fenoly chemie metabolismus škodlivé účinky toxicita MeSH
- kongresy jako téma MeSH
- kyseliny ftalové metabolismus škodlivé účinky toxicita MeSH
- látky znečišťující životní prostředí * normy škodlivé účinky toxicita MeSH
- lidé MeSH
- metabolické nemoci epidemiologie etiologie MeSH
- obezita epidemiologie etiologie MeSH
- triclosan chemie metabolismus škodlivé účinky MeSH
- Check Tag
- lidé MeSH
