Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
19480730
DOI
10.1017/s0007114509389242
PII: S0007114509389242
Knihovny.cz E-zdroje
- MeSH
- chronická nemoc MeSH
- dietní tuky nenasycené farmakologie MeSH
- dietní tuky farmakologie MeSH
- fyziologická adaptace účinky léků fyziologie MeSH
- hypoxie patofyziologie MeSH
- kardiotonika farmakologie MeSH
- katalasa metabolismus MeSH
- krysa rodu Rattus MeSH
- kukuřičný olej farmakologie MeSH
- kyseliny mastné omega-3 farmakologie MeSH
- kyseliny mastné omega-6 farmakologie MeSH
- lipidy krev MeSH
- myokard metabolismus MeSH
- nenasycené mastné kyseliny analýza farmakologie MeSH
- peroxidace lipidů účinky léků MeSH
- potkani Wistar MeSH
- rybí oleje farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- dietní tuky nenasycené MeSH
- dietní tuky MeSH
- kardiotonika MeSH
- katalasa MeSH
- kukuřičný olej MeSH
- kyseliny mastné omega-3 MeSH
- kyseliny mastné omega-6 MeSH
- lard MeSH Prohlížeč
- lipidy MeSH
- nenasycené mastné kyseliny MeSH
- rybí oleje MeSH
The effects of dietary supplementation with fat of different fatty acid profile and chronic intermittent hypoxia (CIH) on the fatty acid composition of serum and heart lipids were analysed. Adult male Wistar rats were fed a standard non-fat diet enriched with 10 % of lard, fish oil (n-3 PUFA) or maize oil (n-6 PUFA) for 10 weeks. After 4 weeks on the diets, each group was divided in two subgroups, either exposed to CIH in a barochamber (7000 m, twenty-five exposures) or kept at normoxia. In normoxic rats, the fish oil diet increased the level of conjugated dienes. The n-6:n-3 PUFA ratio in serum TAG, phospholipids (PL), cholesteryl esters (CE) and heart TAG, PL and diacylglycerols (DAG) followed the ratio in the fed diet (in the sequence maize oil>lard>fish oil). In heart TAG, PL and DAG, 20 : 4n-6 and 18 : 2n-6 were replaced by 22 : 6n-3 in the fish oil group. The main fatty acid in CE was 20 : 4n-6 in the lard and maize oil groups whereas in the fish oil group, half of 20 : 4n-6 was replaced by 20 : 5n-3. CIH further increased 20 : 5n-3 in CE in the fish oil group. CIH decreased the n-6:n-3 PUFA ratio in serum CE, heart TAG, PL and DAG in all dietary groups and stimulated the activity of catalase in the maize and fish oil groups. In conclusion, PUFA diets and CIH, both interventions considered to be cardioprotective, distinctly modified the fatty acid profile in serum and heart lipids with specific effects on conjugated diene production and catalase activity.