Cholesterol metabolism in active Crohn's disease
Language English Country Austria Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cholesterol blood MeSH
- Crohn Disease blood MeSH
- Adult MeSH
- Cholesterol, HDL blood MeSH
- Intestinal Absorption physiology MeSH
- Cholesterol, LDL blood MeSH
- Humans MeSH
- Protein-Energy Malnutrition blood MeSH
- Reference Values MeSH
- Sterols blood MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cholesterol MeSH
- Cholesterol, HDL MeSH
- Cholesterol, LDL MeSH
- Sterols MeSH
Hypocholesterolemia has been investigated as a typical feature of critical illness and is connected with poor prognosis. Crohn's disease is an inflammatory process and is associated with several metabolic disturbances. In recent decades clinical studies have established a link between lipid metabolism and systemic inflammation. In our study we examined the serum profile of cholesterol (total cholesterol, LDL- and HDL-cholesterol) and changes in the cholesterol absorption/synthesis process by determination of plasma non-cholesterol sterol (squalene, lathosterol, campesterol, sitosterol) concentrations. Serum concentrations of total cholesterol, LDL- and HDL-cholesterol and non-cholesterol sterols were evaluated in 24 patients with active Crohn's disease during a period of 28 days. We detected lower serum levels of total cholesterol (P < 0.001), LDL- and HDL-cholesterol (P < 0.05) in the patients with active Crohn's disease than in the control group. In addition, the patients had significantly lower plasma levels of lathosterol (P < 0.001) and higher concentrations of squalene, although without significant differences. A significant decrease of campesterol plasma levels (P < 0.001) was detected, but lower plasma concentrations of sitosterol were without statistical significance. The active phase of Crohn's disease is characterized by altered metabolism of lipids, mainly of cholesterol. Our results show abnormalities in plasma concentrations of non-cholesterol sterols and provide evidence that the process of cholesterol synthesis and absorption is altered in active Crohn's disease.
See more in PubMed
J Gastroenterol Hepatol. 1998 Dec;13(12):1183-90 PubMed
N Engl J Med. 1996 Jun 13;334(24):1557-60 PubMed
JPEN J Parenter Enteral Nutr. 1999 Sep-Oct;23(5 Suppl):S20-4 PubMed
Wien Klin Wochenschr. 2003 Nov 28;115(21-22):740-2 PubMed
J Lipid Res. 2003 Aug;44(8):1489-98 PubMed
Crit Care Med. 2000 Oct;28(10):3574-5 PubMed
Intensive Care Med. 2003 Dec;29(12):2199-2203 PubMed
Am J Clin Nutr. 1986 Jan;43(1):92-7 PubMed
Wien Klin Wochenschr. 2003 Nov 28;115(21-22):775-9 PubMed
J Chromatogr A. 2001 Nov 23;935(1-2):203-36 PubMed
Crit Care Med. 2001 Aug;29(8):1563-8 PubMed
Clin Chem. 2000 Aug;46(8 Pt 1):1114-20 PubMed
Eur J Clin Invest. 1998 Jun;28(6):491-6 PubMed
Eur J Gastroenterol Hepatol. 2003 Feb;15(2):151-7 PubMed
Scand J Gastroenterol. 1999 Nov;34(11):1108-16 PubMed
Aliment Pharmacol Ther. 2003 Aug 15;18(4):433-42 PubMed
Surg Infect (Larchmt). 2004 Spring;5(1):39-49 PubMed
Gut. 2002 Aug;51(2):164-8 PubMed
J Gastroenterol. 2005 Mar;40 Suppl 16:25-31 PubMed
Am J Clin Nutr. 2000 Mar;71(3):807-15 PubMed
Wien Klin Wochenschr. 2003 Nov 28;115(21-22):767-74 PubMed
Clin Chem. 2003 Feb;49(2):317-9 PubMed
Crit Care. 2003 Dec;7(6):R145-53 PubMed
Lancet. 2001 Aug 4;358(9279):351-5 PubMed
Immunol Res. 2001;23(1):41-58 PubMed
