Reduced inducibility of SOCS3 by interferon gamma associates with higher resistance of human breast cancer lines as compared to normal mammary epithelial cells
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
19580338
DOI
10.4149/neo_2009_05_379
Knihovny.cz E-zdroje
- MeSH
- chemorezistence MeSH
- fosforylace MeSH
- interferon gama farmakologie MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- nádory prsu farmakoterapie metabolismus patologie MeSH
- polymerázová řetězová reakce s reverzní transkripcí MeSH
- protein SOCS3 MeSH
- proteiny SOCS genetika MeSH
- prsy účinky léků metabolismus MeSH
- transkripční faktor STAT1 metabolismus MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- interferon gama MeSH
- protein SOCS3 MeSH
- proteiny SOCS MeSH
- SOCS3 protein, human MeSH Prohlížeč
- STAT1 protein, human MeSH Prohlížeč
- transkripční faktor STAT1 MeSH
The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the antiproliferative effect of interferon gamma in relation to SOCS3 expression in a panel of breast cancer cell lines and normal mammary epithelial cells. Compared to normal cells most breast cancer lines (7/8) were highly resistant to IFN-gamma. Using Northern blot and real time RT-PCR we investigated transcription of SOCS3 genes. All normal epithelial cells (4/4) showed SOCS3 induction (2-14 fold) while most breast cancer lines did not or weakly activated SOCS3 after the interferon gamma treatment. Among the cancer lines, the MDA-MB-468 cells showed increased sensitivity to IFN-gamma and relatively high level of SOCS3 induction (2-3 fold). Together, there was a good correlation
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