Resting membrane potential and Na+,K+-ATPase of rat fast and slow muscles during modeling of hypogravity
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19761352
DOI
10.33549/physiolres.931810
PII: 1810
Knihovny.cz E-resources
- MeSH
- Muscle, Skeletal metabolism MeSH
- Rats MeSH
- Membrane Potentials physiology MeSH
- Rats, Wistar MeSH
- Weightlessness Simulation * MeSH
- Sodium-Potassium-Exchanging ATPase metabolism MeSH
- Muscle Contraction physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Sodium-Potassium-Exchanging ATPase MeSH
Antiorthostatic hindlimb suspension (unloading) decreased the resting membrane potential (RMP) of skeletal muscle fibers in fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle of the rat by about 10% within 7 days and more. Inactivation of the membrane Na+,K+-pump by ouabain brought about similar depolarization as unloading. The increased sodium permeability of the membrane was excluded as the major cause of this depolarization by experiments in which TRIS was substituted for Na+ in the medium. On the other hand, the decrease in the electrogenic participation of the Na+,K+-pump is apparently one of the causes of RMP decrease during hypogravity, in EDL muscle in particular.
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