Resting membrane potential and Na+,K+-ATPase of rat fast and slow muscles during modeling of hypogravity
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
19761352
DOI
10.33549/physiolres.931810
PII: 1810
Knihovny.cz E-zdroje
- MeSH
- kosterní svaly metabolismus MeSH
- krysa rodu Rattus MeSH
- membránové potenciály fyziologie MeSH
- potkani Wistar MeSH
- simulace stavu beztíže * MeSH
- sodíko-draslíková ATPasa metabolismus MeSH
- svalová kontrakce fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- sodíko-draslíková ATPasa MeSH
Antiorthostatic hindlimb suspension (unloading) decreased the resting membrane potential (RMP) of skeletal muscle fibers in fast extensor digitorum longus (EDL) and slow soleus (SOL) muscle of the rat by about 10% within 7 days and more. Inactivation of the membrane Na+,K+-pump by ouabain brought about similar depolarization as unloading. The increased sodium permeability of the membrane was excluded as the major cause of this depolarization by experiments in which TRIS was substituted for Na+ in the medium. On the other hand, the decrease in the electrogenic participation of the Na+,K+-pump is apparently one of the causes of RMP decrease during hypogravity, in EDL muscle in particular.
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