Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19958280
DOI
10.2174/092986610790780387
PII: 0084
Knihovny.cz E-resources
- MeSH
- Acylation MeSH
- Biomimetic Materials chemical synthesis chemistry MeSH
- Spectrometry, Mass, Electrospray Ionization MeSH
- Diaminopimelic Acid analogs & derivatives chemical synthesis chemistry MeSH
- Metabolic Networks and Pathways MeSH
- Models, Molecular MeSH
- Succinates chemical synthesis chemistry MeSH
- Succinyldiaminopimelate Transaminase antagonists & inhibitors metabolism MeSH
- Chromatography, High Pressure Liquid MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Diaminopimelic Acid MeSH
- Succinates MeSH
- Succinyldiaminopimelate Transaminase MeSH
The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.
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