Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20002811
DOI
10.1111/j.1744-313x.2009.00890.x
PII: EJI890
Knihovny.cz E-resources
- MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genotype MeSH
- Immunity genetics MeSH
- Actinomycetales Infections genetics microbiology veterinary MeSH
- Polymorphism, Single Nucleotide * MeSH
- Horses MeSH
- Horse Diseases genetics immunology microbiology MeSH
- Polymorphism, Restriction Fragment Length MeSH
- Receptors, Interleukin-7 genetics MeSH
- Rhodococcus equi immunology isolation & purification MeSH
- Sequence Analysis, DNA MeSH
- Trachea microbiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Receptors, Interleukin-7 MeSH
In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio: 8.00, 95% confidence interval: 1.127-56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with infection in this study. SNPs analysed were found by sequencing and appropriate restriction fragment length polymorphism markers were developed. Their associations with R. equi infection were tested by genotyping thoroughbred foals from the original study. The association was confirmed by analysing genotypes composed with genes previously reported to be associated with R. equi infection in the same group.
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