Responsiveness to methamphetamine in adulthood is altered by prenatal exposure in rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20006633
DOI
10.1016/j.physbeh.2009.12.004
PII: S0031-9384(09)00390-4
Knihovny.cz E-resources
- MeSH
- Maze Learning drug effects MeSH
- Rats MeSH
- Methamphetamine administration & dosage pharmacology MeSH
- Exploratory Behavior drug effects MeSH
- Motor Activity drug effects MeSH
- Rats, Wistar MeSH
- Central Nervous System Stimulants administration & dosage pharmacology MeSH
- Pregnancy MeSH
- Anxiety drug therapy MeSH
- Prenatal Exposure Delayed Effects psychology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Methamphetamine MeSH
- Central Nervous System Stimulants MeSH
Methamphetamine (MA) is a drug causing potent psychomotor activation. The aim of the present study was: (1) to assess the effect of prenatal and acute MA administration on behavior in adult male rats and (2) to find out if the prenatal exposure to MA increases sensitivity to acute MA application in adulthood. Behavior of adult male rats prenatally exposed to MA (5mg/kg) or saline was tested in Open field (OF) and Elevated plus maze (EPM). Subcutaneously administered MA (1mg/kg) or saline were used as challenge in adulthood, 30 min prior to testing. Our results showed that prenatal MA did not have an effect on baseline behavior in either of the tests. By contrast, acute MA increased overall psychomotor activity by increasing locomotion and exploratory behavior and decreasing comforting behavior. Moreover, adult rats prenatally exposed to MA exhibited increased sniffing and decreased rearing after acute MA dose in adulthood relative to prenatally saline-exposed rats. In addition, while acute MA application decreased anxiety in rats prenatally exposed to MA, rats prenatally exposed to saline were less sensitive to the anxiolytic effects of MA. Our results indicate that changes caused by prenatal exposure to psychostimulants may become apparent as different reactivity to drugs of abuse when an individual encounters them later in life. In addition, we found that the anxiolytic effect of acute MA (1mg/kg) probably depends also on the reactivity to stress and the activity of hypothalamo-pituitary-adrenal axis.
References provided by Crossref.org
Perinatal Stress and Methamphetamine Exposure Decreases Anxiety-Like Behavior in Adult Male Rats
Age-related differences in NMDA receptor subunits of prenatally methamphetamine-exposed male rats
